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EPN

1. What is EPN?

EPN : Electroporation Needle system

EPN is the new generation of emerging technology with combining automatic needling (Auto Microneedle Therapy System, Auto MTS) and electroporation to effectively deliver a drug. EPN permits (by Auto MTS and electroporation) to effectively deliver a drug into different tissue depths within face or scalp. By needling on the underlying skin tissue in shorter treatment times, it achieves more effective drug delivery through electrostimulating micro-pores that provides less discomfort to the patient.

Clinical Indication

  • Hair regeneration
  • Improving Surface scar & Deep scar
  • Skin brightening
  • Skin firming
  • Pore contraction
  • Improving wrinkle

2. EPN Principle

2.1. Automatic needling (Auto MTS)

  • Induces an effective drug delivery stimulating tissue by
    micro-needling and drug to permeate into the tissue
  • Induces a drug with the high molecular weight to
    permeate into the dermal layer
  • Induces skin tissue on scar tissue to regenerate
    throughout micro-pores

2.2. Microneedle electroporation

  • Can be activated by microneedles penetrated into the dermal layer
  • Makes micro-pores instantly on dermal fibroblast membranes
  • Induces a drug with the high molecular weight to permeate into the fibroblasts

3. Mechanism of Action

Control panel

 

 

 

 

LCD

 

 

 

 

 

4. Device Feature & Technology

Microneedle + electroporation

Synergy effects of drug penetration

Result

(a) (a) Intact skin – penetration depth 30 μm

(b) (b) Microneedle only – penetration depth 60 μm

(c) (c) IN-SKIN EP (200 V, 10 ms, 10 pulses)

Materials and methods

  • Animal: Male hairless rats (Abdomen)
  • Chemical: FD-4 (Fluorescein isothiocyanate (FITC)-
    dextran. Molecular weight 4.3 kDa)
  • Observation: Fluorescence confocal laser scanning
  • Electroporation: 200V / 10ms / 10 pulse
  • Microneedle
    IN-SKIN EP
  • Microneedle penetration depth: 0.4 mm

Reference
Yan K, Todo H, Sugibayashi K. Transdermal drug delivery by in-skin electroporation using a microneedle array. Int J Pharm. 2010 Sep 15;397(1-2):77-83.

Microneedle with electroporation can effectively deliver high molecular and hydrophilic drugs.

Electroporation

Nine needle electrodes placed in a circle

  • 8 electrodes circular placement +single electrode central placement

(+), (-) Cross-placement

 

 

 

 

 

 

 

 

EPN provide constant electric field to all the tissue between the electrodes.

Ergonomic design

  • A non-slip grip
  • Operator-friendly handle as a pen type, enabling fatigue-free procedures
  • Direct access to mount and dismount

5. Clinical report

  • Patient: Androgenetic alopecia patient
  • Treatment region: Scalp
  • Treatment cycle: 1 time per week
  • Patient: alopecia patient
  • Treatment region: Scalp (crown of the head)
  • Treatment cycle: 1 time per week
  • Patient: alopecia patient
  • Treatment region: Scalp (crown of the head)
  • Treatment cycle: 1 time per week
  • Treatment region: Face
  • Treatment cycle: 1 time per week

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